Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981333 | 0.78 | POLB (1.00) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL2652841 | 0.77 | ABCB1 (0.65) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL17616019 | 0.75 | MEN1 (1.00) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL30704438 | 0.74 | MEN1 (0.73) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL27353440 | 0.74 | MEN1 (0.73) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL12039630 | 0.72 | NPC1 (0.93) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL13425992 | 0.72 | ABCB1 (0.72) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL8660452 | 0.72 | ABCB1 (0.59) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL14034689 | 0.72 | MEN1 (0.60) | ABCB1POLBTDP1MEN1KMT2A | |
| SCHEMBL11135578 | 0.72 | MAOA (0.63) | ABCB1POLBTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |