Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.47 |
| ▸ | PPARA | Q07869 | 6/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | GCGR | P47871 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GIPR | P48546 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655041 | 0.85 | PPARD (0.50) | PPARDPPARAPPARGGCGREPHX2 | |
| SCHEMBL2652102 | 0.85 | PPARD (0.49) | PPARDPPARAPPARGGCGREPHX2 | |
| SCHEMBL2653326 | 0.82 | MEN1 (0.57) | GCGREPHX2GIPR | |
| SCHEMBL2652593 | 0.82 | MEN1 (0.57) | GCGREPHX2GIPR | |
| SCHEMBL2655721 | 0.81 | MEN1 (0.56) | GCGREPHX2GIPR | |
| SCHEMBL2651906 | 0.81 | MEN1 (0.56) | GCGREPHX2GIPR | |
| SCHEMBL2653574 | 0.80 | MEN1 (0.55) | GCGREPHX2GIPR | |
| SCHEMBL2654985 | 0.80 | MEN1 (0.55) | GCGREPHX2GIPR | |
| SCHEMBL2661613 | 0.80 | MEN1 (0.55) | GCGREPHX2GIPR | |
| SCHEMBL2652886 | 0.80 | MEN1 (0.55) | GCGREPHX2GIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |