Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653431 | 0.96 | HPGD (0.47) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2654294 | 0.95 | MEN1 (0.41) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2653246 | 0.90 | FFAR4 (0.43) | MEN1KMT2APPARAPPARGPPARD | |
| SCHEMBL2653931 | 0.89 | HPGD (0.39) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2652510 | 0.87 | FFAR4 (0.42) | MEN1KMT2AALDH1A1PPARAPPARG | |
| SCHEMBL2655151 | 0.87 | PPARA (0.39) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2653567 | 0.87 | PPARD (0.41) | HPGDMEN1KMT2AMAPTTRPV1 | |
| SCHEMBL2653083 | 0.87 | HPGD (0.41) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2653599 | 0.86 | FFAR4 (0.41) | MEN1KMT2AALDH1A1PPARAPPARG | |
| SCHEMBL2655570 | 0.86 | FFAR4 (0.41) | MEN1KMT2AALDH1A1PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |