Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.39 |
| ▸ | PPARD | Q03181 | 10/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GIPR | P48546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652401 | 0.93 | GCGR (0.35) | GCGRPPARDEPHX2 | |
| SCHEMBL2652643 | 0.93 | GCGR (0.46) | GCGRPPARDPPARGPPARAGIPR | |
| SCHEMBL2653672 | 0.90 | GCGR (0.39) | GCGRPPARDPPARGPPARAEPHX2 | |
| SCHEMBL2653251 | 0.90 | GCGR (0.37) | GCGRPPARDPPARAEPHX2 | |
| SCHEMBL9072397 | 0.88 | PPARD (0.41) | GCGRPPARDPPARGPPARA | |
| SCHEMBL2653567 | 0.85 | PPARD (0.41) | GCGRPPARDPPARGPPARAEPHX2 | |
| SCHEMBL2653286 | 0.85 | GCGR (0.42) | GCGR | |
| SCHEMBL2654679 | 0.85 | PPARD (0.42) | GCGRPPARDPPARGPPARAEPHX2 | |
| SCHEMBL2653895 | 0.85 | GCGR (0.38) | GCGRPPARDPPARGPPARASLC1A3 | |
| SCHEMBL2655425 | 0.83 | GCGR (0.37) | GCGRPPARDPPARGPPARAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |