Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 7/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653189 | 0.86 | KDM4E (0.41) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL2653187 | 0.86 | KDM4E (0.41) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL6600649 | 0.80 | HDAC1 (0.56) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL4236820 | 0.77 | PRKCI (0.53) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL1418704 | 0.77 | HDAC1 (0.56) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL14972936 | 0.72 | IP6K1 (0.63) | HDAC1POLBPRKCIMAPTKMT2A | |
| SCHEMBL30050466 | 0.72 | IP6K1 (0.63) | HDAC1POLBPRKCIMAPTKMT2A | |
| SCHEMBL10817405 | 0.72 | IP6K1 (0.63) | HDAC1POLBPRKCIMAPTKMT2A | |
| SCHEMBL15354273 | 0.72 | PTK6 (0.53) | HDAC1POLBPRKCIMAPTTDP1 | |
| SCHEMBL4574406 | 0.71 | HDAC1 (0.70) | HDAC1POLBPRKCIMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874758-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2008-01-09 | — | — | EP | claimed |
| WO-2006111516-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-26 | — | — | WO | claimed |
| EP-1874758-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111516-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-26 | — | — | WO | disclosed |