Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | ESRRG | P62508 | 3/20 | 0.34 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | GCG | P01275 | 1/20 | 0.34 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.34 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.34 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.34 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654382 | 0.95 | GCGR (0.44) | GCGRKMT2AMCL1ACKR3MAPT | |
| SCHEMBL2655204 | 0.93 | GCGR (0.42) | GCGRKMT2AMCL1MAPTGIPR | |
| SCHEMBL2655317 | 0.92 | GCGR (0.39) | GCGRACKR3MAPTESRRGESRRB | |
| SCHEMBL2653982 | 0.91 | GCGR (0.44) | GCGRKMT2AMCL1ACKR3GIPR | |
| SCHEMBL2653160 | 0.90 | GCGR (0.46) | GCGRKMT2AMCL1ACKR3MAPT | |
| SCHEMBL2653026 | 0.88 | GCGR (0.44) | GCGRKMT2AMCL1ACKR3MAPT | |
| SCHEMBL13647296 | 0.88 | GCGR (0.47) | GCGRKMT2AMCL1ACKR3MAPT | |
| SCHEMBL2653596 | 0.87 | GCGR (0.44) | GCGRKMT2AMCL1ACKR3MAPT | |
| SCHEMBL2658618 | 0.86 | GRIA4 (0.37) | MAPT | |
| SCHEMBL2652959 | 0.86 | GCGR (0.43) | GCGRKMT2AMCL1ACKR3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |