Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.34 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653596 | 0.99 | GCGR (0.44) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2653026 | 0.97 | GCGR (0.44) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2653160 | 0.93 | GCGR (0.46) | GCGRACKR3KMT2AMCL1GIPR | |
| SCHEMBL2662579 | 0.92 | MCL1 (0.42) | GCGRALDH1A1LMNAPRNPRECQL | |
| SCHEMBL2653235 | 0.92 | MCL1 (0.43) | GCGRALDH1A1LMNAPRNPRECQL | |
| SCHEMBL2654382 | 0.88 | GCGR (0.44) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL13647296 | 0.88 | GCGR (0.47) | GCGRACKR3KMT2AMCL1GIPR | |
| SCHEMBL2654422 | 0.87 | GCGR (0.49) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2656441 | 0.86 | GRIA4 (0.38) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2653293 | 0.86 | GCGR (0.45) | GCGRACKR3KMT2AMCL1FOLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |