Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | F7 | P08709 | 3/20 | 0.44 |
| ▸ | F3 | P13726 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774561 | 1.00 | MEN1 (0.63) | MEN1KMT2ANR4A2PDE4DPDE4A | |
| SCHEMBL1427097 | 0.93 | MEN1 (0.66) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1427488 | 0.89 | LMNA (0.49) | MEN1KMT2APDE4DPDE4APDE4B | |
| SCHEMBL1427102 | 0.84 | KMT2A (0.71) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1427078 | 0.82 | LMNA (0.51) | MEN1KMT2AALDH1A1F10PRSS1 | |
| SCHEMBL338207 | 0.81 | MAOB (0.50) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1776651 | 0.81 | GCK (0.53) | GCKGRM5 | |
| SCHEMBL7357911 | 0.81 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1427203 | 0.79 | GCK (0.64) | GCKGRM5 | |
| SCHEMBL1427378 | 0.79 | GCK (0.64) | GCKGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891069-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B]PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |