Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.49 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.49 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.49 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.49 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.49 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.49 |
| ▸ | ADCY7 | P51828 | 3/20 | 0.49 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.49 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.49 |
| ▸ | ADCY4 | Q8NFM4 | 3/20 | 0.49 |
| ▸ | GIPR | P48546 | 2/20 | 0.49 |
| ▸ | GCG | P01275 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654579 | 0.91 | PPARD (0.43) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2653428 | 0.91 | GCGR (0.58) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2654147 | 0.90 | FFAR1 (0.48) | GCGRGIPRGCGS1PR1PPARA | |
| SCHEMBL2654059 | 0.89 | GCGR (0.50) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2653527 | 0.89 | GCGR (0.55) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2654644 | 0.89 | GCG (0.47) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2652048 | 0.87 | GCGR (0.48) | GCGRGIPRGCGPPARD | |
| SCHEMBL2269791 | 0.84 | MAOB (0.58) | GCGRGIPRS1PR1PPARAPPARD | |
| SCHEMBL2655409 | 0.84 | GCGR (0.51) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2655260 | 0.83 | GCGR (0.45) | GCGRGIPRPPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |