Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 3/20 | 0.41 |
| ▸ | GIPR | P48546 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653943 | 0.91 | NR1H4 (0.48) | MEN1KMT2AEPHX2GCGRADCY6 | |
| SCHEMBL2653550 | 0.91 | GCGR (0.49) | PPARDEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL2662283 | 0.90 | MEN1 (0.46) | MEN1KMT2AMAOBSPHK2MAPK14 | |
| SCHEMBL2654679 | 0.89 | PPARD (0.42) | PPARDEPHX2PPARGPPARAGCGR | |
| SCHEMBL2653911 | 0.84 | GCGR (0.43) | PPARDMEN1KMT2AEPHX2PPARG | |
| SCHEMBL2653251 | 0.83 | GCGR (0.37) | PPARDEPHX2SPHK2PPARAGCGR | |
| SCHEMBL2653962 | 0.83 | MEN1 (0.58) | MEN1KMT2AMAOBSPHK2MAPK14 | |
| SCHEMBL2272970 | 0.82 | PPARG (0.47) | PPARDEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL2653428 | 0.82 | GCGR (0.58) | EPHX2GCGRGIPRADCY6ADCY3 | |
| SCHEMBL2653250 | 0.82 | MEN1 (0.57) | MEN1KMT2AMAOBSPHK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |