Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | GCG | P01275 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 6/20 | 0.49 |
| ▸ | GIPR | P48546 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.46 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.46 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.46 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.46 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654622 | 0.94 | GCG (0.53) | NPC1RAB9APOLBCASP3SENP7 | |
| SCHEMBL2651583 | 0.91 | GCGR (0.49) | NPC1RAB9AGCGGCGRGIPR | |
| SCHEMBL2652475 | 0.91 | GCGR (0.49) | NPC1RAB9AGCGGCGRGIPR | |
| SCHEMBL2653041 | 0.91 | GCGR (0.49) | NPC1RAB9AGCGGCGRGIPR | |
| SCHEMBL2651638 | 0.91 | GCGR (0.49) | NPC1RAB9AGCGGCGRGIPR | |
| SCHEMBL2651800 | 0.91 | CASP3 (0.53) | NPC1RAB9ACASP3SENP7GCG | |
| SCHEMBL2651512 | 0.91 | GCG (0.51) | NPC1RAB9AGCGGCGRSMN1; SMN2 | |
| SCHEMBL2653154 | 0.91 | GCG (0.53) | NPC1RAB9ACASP3SENP7GCG | |
| SCHEMBL2651554 | 0.90 | SMN1; SMN2 (0.58) | NPC1RAB9ACASP3SENP7GCG | |
| SCHEMBL2652203 | 0.90 | GCGR (0.50) | NPC1RAB9AGCGGCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | claimed |
| WO-2003016311-A1 | TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS LIGANDS FOR GABA-A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-02-27 | — | — | WO | claimed |