Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | MLYCD | O95822 | 2/20 | 0.52 |
| ▸ | GCGR | P47871 | 4/20 | 0.50 |
| ▸ | GIPR | P48546 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652235 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2654122 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2654583 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2653574 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2652886 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2653662 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2654985 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2661613 | 0.91 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1FFAR1 | |
| SCHEMBL2653174 | 0.90 | GCGR (0.50) | EPHX2MLYCDGCGRGIPR | |
| SCHEMBL2655431 | 0.90 | EPHX2 (0.47) | EPHX2MLYCDGCGRGIPRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |