Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 9/20 | 0.47 |
| ▸ | GIPR | P48546 | 5/20 | 0.47 |
| ▸ | MLYCD | O95822 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654871 | 0.92 | SLC13A5 (0.45) | GCGRGIPRMLYCD | |
| SCHEMBL2653591 | 0.90 | EPHX2 (0.56) | EPHX2GCGRGIPRMLYCDHRH3 | |
| SCHEMBL2654640 | 0.89 | MEN1 (0.43) | MLYCDPPARDPPARAPLA2G4B | |
| SCHEMBL2655586 | 0.89 | GCGR (0.48) | EPHX2GCGRGIPRPPARA | |
| SCHEMBL2656017 | 0.88 | S1PR1 (0.53) | GCGRHRH3S1PR1 | |
| SCHEMBL2653397 | 0.88 | HSD17B10 (0.49) | HRH3S1PR1PLA2G4B | |
| SCHEMBL2661613 | 0.84 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1 | |
| SCHEMBL2653662 | 0.84 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1 | |
| SCHEMBL2654985 | 0.84 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1 | |
| SCHEMBL2654122 | 0.84 | MEN1 (0.55) | EPHX2GCGRGIPRS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |