SCHEMBL265361

SCHEMBL265361

Cc1ccc(CCOCCNS(=O)(=O)CCCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1

nearest known ligand 0.71

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 2/20 0.71
ADRB2 P07550 18/20 0.63
ADRB1 P08588 1/20 0.63
DRD2 P14416 1/20 0.63
PDE4A P27815 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30438565 1.00 ABCB11 (0.71) ABCB11ADRB2ADRB1DRD2PDE4A
Hydrochloric Acid SCHEMBL5051545 0.99 ABCB11 (0.70) ABCB11ADRB2ADRB1DRD2PDE4A
SCHEMBL8088585 0.92 ABCB11 (0.71) ABCB11ADRB2ADRB1DRD2PDE4A
SCHEMBL8104306 0.92 ABCB11 (0.71) ABCB11ADRB2ADRB1DRD2PDE4A
SCHEMBL8095472 0.92 ABCB11 (0.84) ABCB11ADRB2ADRB1DRD2PDE4A
Hydrochloric Acid SCHEMBL8097788 0.91 ABCB11 (0.70) ABCB11ADRB2ADRB1DRD2PDE4A
Hydrochloric Acid SCHEMBL8098171 0.91 ABCB11 (0.70) ABCB11ADRB2ADRB1DRD2PDE4A
Hydrochloric Acid SCHEMBL8088900 0.91 ABCB11 (0.82) ABCB11ADRB2ADRB1DRD2PDE4A
SCHEMBL8095311 0.88 ABCB11 (0.62) ABCB11ADRB2ADRB1DRD2PDE4A
SCHEMBL8088395 0.88 ABCB11 (0.67) ABCB11ADRB2ADRB1DRD2PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2448623-B1 DISPENSER AND METHOD FOR ENTRAINING POWDER IN AN AIRFLOW ASTRAZENECA AB (SE) 2017-12-20 EP claimed
EP-2341968-B1 A BREATH ACTIVATED INHALER ASTRAZENECA AB (SE) 2017-05-10 EP claimed
US-9289565-B2 Inhaler with indexing linked to movement of cover ASTRAZENECA AB (SE) 2016-03-22 US claimed
EP-2334358-B1 INHALATION DEVICE FOR DISPENSING MEDICAMENT ASTRAZENECA AB (SE) 2016-02-10 EP claimed
US-9155851-B2 Breath activated inhaler ASTRAZENECA AB (SE) 2015-10-13 US claimed
US-9095670-B2 Inhalation device and method of dispensing medicament ASTRAZENECA AB (SE) 2015-08-04 US claimed
EP-2595683-B1 Inhaler ASTRAZENECA AB (SE) 2015-03-04 EP claimed
US-20140083422-A1 INHALER ASTRAZENECA AB 2014-03-27 US claimed
US-8578933-B2 Entraining powder in an airflow ASTRAZENECA AB (SE) 2013-11-12 US claimed
EP-2595683-A2 INHALER AstraZeneca AB (SE) 2013-05-29 EP claimed
US-20050106335-A1 Novel process for coating inhalation devices ASTRAZENECA AB (SE) 2005-05-19 US claimed
EP-1345591-B1 PHARMACEUTICAL AEROSOL FORMULATION ASTRAZENECA AB (SE) 2005-03-02 EP claimed
EP-1474197-A1 NOVEL PROCESS FOR COATING INHALATION DEVICES AstraZeneca AB (SE) 2004-11-10 EP claimed
US-20030194378-A1 Novel aerosol formulation containing a polar fluorinated molecule ASTRAZENECA AB (SE) 2003-10-16 US claimed
EP-1345591-A1 PHARMACEUTICAL AEROSOL FORMULATION AstraZeneca AB (SE) 2003-09-24 EP claimed
WO-2003063938-A1 NOVEL PROCESS FOR COATING INHALATION DEVICES ASTRAZENECA AB (SE) 2003-08-07 WO claimed
EP-1303258-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE AstraZeneca AB (SE) 2003-04-23 EP claimed
WO-2002049616-A1 PHARMACEUTICAL AEROSOL FORMULATION ASTRAZENECA AB (SE) 2002-06-27 WO claimed
WO-2002003958-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE ASTRAZENECA AB (SE) 2002-01-17 WO claimed
EP-0850232-B1 BENZOTHIAZOLONE DERIVATIVES ASTRA PHARMA PROD (GB) 2000-03-15 EP claimed