SCHEMBL2653641

SCHEMBL2653641

CC(C)(C)c1ccc(Nc2cccc(C(=O)O)c2)c([N+](=O)[O-])c1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 5/20 0.79
AKR1C2 P52895 5/20 0.79
AKR1C4 P17516 4/20 0.79
AKR1C1 Q04828 4/20 0.79
AKR1B1 P15121 2/20 0.79
AKR1B10 O60218 1/20 0.68
NPC1 O15118 1/20 0.65
ALDH1A1 P00352 1/20 0.65
GLA P06280 1/20 0.65
MAPK1 P28482 1/20 0.65
CASP3 P42574 1/20 0.65
HTT P42858 1/20 0.65
RAB9A P51151 1/20 0.65
SENP8 Q96LD8 1/20 0.65
SENP7 Q9BQF6 1/20 0.65
SENP6 Q9GZR1 1/20 0.65
HCAR3 P49019 2/20 0.63
AR P10275 1/20 0.62
MAPT P10636 4/20 0.61
HPGD P15428 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7439285 0.84 AKR1C4 (0.72) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL1668098 0.81 AKR1B1 (0.53) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL30839074 0.81 AKR1C3 (0.72) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL28559163 0.79 CDC25B (0.65) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL2338616 0.78 HCAR3 (1.00) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL4491879 0.77 HCAR3 (0.72) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL23675146 0.77 HCAR3 (0.76) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL13280197 0.77 AKR1C4 (1.00) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL4484306 0.77 HCAR3 (0.76) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1
SCHEMBL2338144 0.77 HCAR3 (0.76) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0616807-B1 Benzimidazole useful in the treatment of central nervous system disorders NEUROSEARCH AS (DK) 1998-07-08 EP disclosed
US-5554632-A CENTRAL NERVOUS SYSTEM NEUROSEARCH A/S (DK) 1996-09-10 US disclosed
US-5554630-A TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES NEUROSEARCH A/S (DK) 1996-09-10 US disclosed
EP-0616807-A1 Benzimidazole useful in the treatment of central nervous system disorders NEUROSEARCH A/S (DK) 1994-09-28 EP disclosed