Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654229 | 0.97 | HPGD (0.48) | HPGDMCL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL9072476 | 0.88 | SMN1; SMN2 (0.39) | HPGDSMN1; SMN2MAPTLMNANAMPT | |
| SCHEMBL2653812 | 0.84 | GCGR (0.42) | HPGDMCL1MAPTNPC1RAB9A | |
| SCHEMBL2653931 | 0.83 | HPGD (0.39) | HPGDMCL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2653014 | 0.83 | SMN1; SMN2 (0.36) | HPGDMCL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2652386 | 0.81 | GCGR (0.42) | HPGDMCL1MAPTNPC1RAB9A | |
| SCHEMBL2653247 | 0.81 | HPGD (0.39) | HPGDMCL1MAPTNPC1RAB9A | |
| SCHEMBL2654307 | 0.81 | HPGD (0.43) | HPGDMCL1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL2653083 | 0.81 | HPGD (0.41) | HPGDMCL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2652772 | 0.80 | HPGD (0.42) | HPGDMCL1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |