Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654006 | 0.86 | GCGR (0.35) | SMN1; SMN2MAPTS1PR1S1PR3HPGD | |
| SCHEMBL9072476 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTHPGDLMNANAMPT | |
| SCHEMBL2653233 | 0.85 | GCGR (0.43) | SMN1; SMN2MAPTS1PR1S1PR3MCL1 | |
| SCHEMBL2653672 | 0.84 | GCGR (0.39) | SMN1; SMN2MAPTMCL1LMNAEPHX2 | |
| SCHEMBL2653090 | 0.84 | HDAC3 (0.38) | EPHX2 | |
| SCHEMBL2653792 | 0.83 | HPGD (0.46) | SMN1; SMN2MAPTHPGDMCL1LMNA | |
| SCHEMBL2654229 | 0.82 | HPGD (0.48) | SMN1; SMN2MAPTHPGDMCL1LMNA | |
| SCHEMBL2654035 | 0.82 | HPGD (0.38) | SMN1; SMN2MAPTS1PR1S1PR3HPGD | |
| SCHEMBL2652401 | 0.82 | GCGR (0.35) | S1PR1S1PR3EPHX2 | |
| SCHEMBL2653837 | 0.81 | HPGD (0.40) | SMN1; SMN2MAPTHPGDLMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |