Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653138 | 0.85 | MCL1 (0.47) | HDAC3HDAC4HDAC1HDAC6MCL1 | |
| SCHEMBL2654336 | 0.83 | MAPT (0.45) | HDAC3HDAC4HDAC1HDAC6MAPT | |
| SCHEMBL2654045 | 0.79 | MAPT (0.43) | HDAC3HDAC4HDAC1HDAC6MAPT | |
| SCHEMBL2653034 | 0.78 | HPGD (0.43) | HDAC1HDAC6MAPTKDM4EMEN1 | |
| SCHEMBL2653246 | 0.77 | FFAR4 (0.43) | MEN1KMT2AMCL1PPARAPPARD | |
| SCHEMBL2666531 | 0.77 | MEN1 (0.47) | HDAC3HDAC4HDAC1HDAC6MAPT | |
| SCHEMBL2652510 | 0.74 | FFAR4 (0.42) | HDAC3HDAC4HDAC1HDAC6MEN1 | |
| SCHEMBL2653431 | 0.74 | HPGD (0.47) | HDAC3HDAC4HDAC1HDAC6MAPT | |
| SCHEMBL3333478 | 0.74 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC6MAPT | |
| SCHEMBL2653917 | 0.74 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |