SCHEMBL26539693

SCHEMBL26539693

COC(=O)c1ccc2c(c1)CCCC(c1ccc(C)cc1Cl)=C2c1ccc(OC2CCN(CCCF)C2)cc1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 20/20 0.80
ESR2 Q92731 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29836645 1.00 ESR1 (0.80) ESR1ESR2
SCHEMBL29500096 0.94 ESR1 (0.85) ESR1ESR2
SCHEMBL19154851 0.94 ESR1 (0.85) ESR1ESR2
SCHEMBL29836706 0.94 ESR1 (0.85) ESR1ESR2
SCHEMBL31114508 0.94 ESR1 (0.85) ESR1ESR2
SCHEMBL19132116 0.94 ESR1 (0.85) ESR1ESR2
SCHEMBL23196308 0.94 ESR1 (0.79) ESR1ESR2
SCHEMBL29836629 0.93 ESR1 (0.86) ESR1ESR2
SCHEMBL23162929 0.93 ESR1 (0.86) ESR1ESR2
SCHEMBL23163032 0.93 ESR1 (0.86) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4037768-B1 NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF SANOFI SA (FR) 2023-10-11 EP disclosed