Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.44 |
| ▸ | ESRRG | P62508 | 7/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654950 | 0.92 | GCGR (0.46) | GCGRESRRGNR1H4EPHX2NPC1 | |
| SCHEMBL2654628 | 0.85 | GCGR (0.43) | GCGR | |
| SCHEMBL2654812 | 0.84 | GCGR (0.51) | GCGRESRRGNR1H4EPHX2NPC1 | |
| SCHEMBL2653226 | 0.84 | GCGR (0.41) | GCGRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2655611 | 0.83 | GCGR (0.60) | GCGRESRRGNR1H4EPHX2NPC1 | |
| SCHEMBL2655395 | 0.79 | GCGR (0.41) | GCGRMEN1KMT2ALMNAMAPT | |
| SCHEMBL2655103 | 0.78 | GCGR (0.47) | GCGRESRRGNPC1RAB9AMEN1 | |
| SCHEMBL1765422 | 0.77 | GCGR (0.57) | GCGRNR1H4EPHX2NPC1RAB9A | |
| SCHEMBL2653229 | 0.77 | GCGR (0.47) | GCGRESRRGNPC1RAB9AMEN1 | |
| SCHEMBL2653584 | 0.77 | GCGR (0.56) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |