Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.56 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | GIPR | P48546 | 2/20 | 0.42 |
| ▸ | GCG | P01275 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | GLP1R | P43220 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654727 | 0.95 | GCGR (0.55) | GCGRPPARAPPARDGIPRGCG | |
| SCHEMBL2655611 | 0.93 | GCGR (0.60) | GCGRGIPR | |
| SCHEMBL2655103 | 0.92 | GCGR (0.47) | GCGRPPARAPPARDPPARG | |
| SCHEMBL2655300 | 0.91 | GCGR (0.53) | GCGRGIPRGLP1R | |
| SCHEMBL2654661 | 0.89 | GCGR (0.55) | GCGRGIPRGCG | |
| SCHEMBL2655085 | 0.88 | GCGR (0.46) | GCGRPPARAPPARDGIPRGCG | |
| SCHEMBL2653639 | 0.88 | GCGR (0.56) | GCGRPPARAPPARDGIPRGCG | |
| SCHEMBL2655868 | 0.87 | GCGR (0.46) | GCGRPPARAPPARD | |
| SCHEMBL2654811 | 0.87 | GCGR (0.59) | GCGRGIPRGCGCHRM5GLP1R | |
| SCHEMBL2654191 | 0.87 | PPARD (0.42) | GCGRPPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |