Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.46 |
| ▸ | PPARD | Q03181 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654749 | 0.97 | GCGR (0.46) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2655313 | 0.97 | GCGR (0.45) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2654407 | 0.92 | GCGR (0.42) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2666496 | 0.91 | GCGR (0.48) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2653567 | 0.90 | PPARD (0.41) | GCGRPPARDPPARGPPARA | |
| SCHEMBL2656490 | 0.90 | GCGR (0.41) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2652922 | 0.90 | GCGR (0.46) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2656127 | 0.89 | GCGR (0.41) | GCGRPPARDPPARGPPARAFFAR4 | |
| SCHEMBL2654428 | 0.89 | GCGR (0.44) | GCGRPPARDPPARGPPARAMCL1 | |
| SCHEMBL2653246 | 0.88 | FFAR4 (0.43) | GCGRPPARDPPARGPPARAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |