Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | GIPR | P48546 | 4/20 | 0.38 |
| ▸ | GCG | P01275 | 3/20 | 0.38 |
| ▸ | GLP1R | P43220 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654086 | 0.93 | GCGR (0.40) | GCGRMCL1PPARDPPARGPPARA | |
| SCHEMBL2652676 | 0.93 | GCGR (0.51) | GCGRMCL1GIPR | |
| SCHEMBL2653132 | 0.92 | GCGR (0.46) | GCGRMCL1PPARDPPARGPPARA | |
| SCHEMBL2655418 | 0.91 | FFAR1 (0.40) | GCGRMCL1PPARAGIPRGCG | |
| SCHEMBL2654266 | 0.91 | GCGR (0.43) | GCGRPPARDGIPR | |
| SCHEMBL2654239 | 0.91 | GCGR (0.41) | GCGRMCL1GIPRGCG | |
| SCHEMBL2653999 | 0.90 | FFAR1 (0.41) | GCGRMCL1PPARGPPARA | |
| SCHEMBL2652866 | 0.90 | GCGR (0.43) | GCGRPPARDPPARGPPARAGIPR | |
| SCHEMBL2653953 | 0.89 | GCGR (0.43) | GCGRMCL1GIPRGCGVIPR2 | |
| SCHEMBL2655038 | 0.89 | GCGR (0.39) | GCGRMCL1PPARDPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |