Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.43 |
| ▸ | GIPR | P48546 | 7/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GCG | P01275 | 2/20 | 0.34 |
| ▸ | VIPR2 | P41587 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | VIPR1 | P32241 | 1/20 | 0.34 |
| ▸ | DUSP2 | Q05923 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654239 | 0.93 | GCGR (0.41) | GCGRGIPRFFAR1MCL1KMT2A | |
| SCHEMBL2653999 | 0.92 | FFAR1 (0.41) | GCGRFFAR1MCL1KMT2A | |
| SCHEMBL2653891 | 0.91 | GCGR (0.42) | GCGRGIPRMCL1KMT2AGCG | |
| SCHEMBL2655038 | 0.91 | GCGR (0.39) | GCGRFFAR1MCL1KMT2AGCG | |
| SCHEMBL2652676 | 0.90 | GCGR (0.51) | GCGRGIPRFFAR1MCL1KMT2A | |
| SCHEMBL2654214 | 0.89 | GCGR (0.38) | GCGRFFAR1MCL1KMT2A | |
| SCHEMBL2654440 | 0.89 | GCGR (0.47) | GCGRGIPRMCL1GCGVIPR2 | |
| SCHEMBL2654266 | 0.89 | GCGR (0.43) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2654772 | 0.88 | GCGR (0.36) | GCGRFFAR1MCL1KMT2AGCG | |
| SCHEMBL2653101 | 0.88 | GCGR (0.42) | GCGRGIPRFFAR1MCL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |