Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | GCK | P35557 | 17/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126322 | 0.91 | GCK (0.54) | KCNH2GCK | |
| SCHEMBL9070770 | 0.89 | KCNH2 (0.55) | KCNH2GCK | |
| SCHEMBL5115061 | 0.89 | KCNH2 (0.71) | KCNH2GCK | |
| SCHEMBL2655582 | 0.88 | KCNH2 (0.53) | KCNH2GCK | |
| SCHEMBL2656905 | 0.86 | KCNH2 (0.54) | KCNH2GCK | |
| SCHEMBL4178604 | 0.85 | GCK (0.69) | GCK | |
| SCHEMBL2668363 | 0.85 | KCNH2 (0.57) | KCNH2GCK | |
| SCHEMBL2668368 | 0.85 | KCNH2 (0.50) | KCNH2GCK | |
| SCHEMBL2668367 | 0.84 | KCNH2 (0.51) | KCNH2GCK | |
| SCHEMBL2668362 | 0.83 | GCK (0.57) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| EP-1948645-A1 | TRICYCLO SUBSTITUTED AMIDES | Prosidion Limited (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007051846-A1 | TRICYCLO SUBSTITUTED AMIDES | PROSIDION LTD (GB) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007051846-A1 | TRICYCLO SUBSTITUTED AMIDES | PROSIDION LTD (GB) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | GPR119, SLC5A2, SLC5A1 | KCNH2 1431/4885GCK 38/4885S1PR1 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.