Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.97 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.97 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796445 | 1.00 | CYP4A11 (0.97) | CYP4A11CYP4F2POLBLOXL2DHODH | |
| SCHEMBL2654036 | 1.00 | CYP4A11 (0.97) | CYP4A11CYP4F2POLBLOXL2DHODH | |
| SCHEMBL2653147 | 1.00 | CYP4A11 (0.97) | CYP4A11CYP4F2POLBLOXL2DHODH | |
| SCHEMBL1628660 | 0.98 | CYP4A11 (1.00) | CYP4A11CYP4F2POLBLOXL2DHODH | |
| SCHEMBL2654777 | 0.93 | CYP4A11 (1.00) | CYP4A11CYP4F2POLBLOXL2DHODH | |
| 1,4-Butanediol SCHEMBL2722579 | 0.87 | CYP4A11 (0.79) | CYP4A11CYP4F2POLBLOXL2ALDH1A1 | |
| SCHEMBL6069166 | 0.86 | CYP4A11 (0.73) | CYP4A11CYP4F2ALDH1A1MAPT | |
| SCHEMBL12814607 | 0.86 | CYP4A11 (0.73) | CYP4A11CYP4F2ALDH1A1MAPT | |
| SCHEMBL10610263 | 0.86 | CYP4A11 (0.73) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL14660877 | 0.86 | CYP4A11 (0.73) | CYP4A11CYP4F2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |