Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GCG | P01275 | 4/20 | 0.43 |
| ▸ | GIPR | P48546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656558 | 0.90 | GCGR (0.45) | GCGRGCGGIPR | |
| SCHEMBL2654802 | 0.90 | GCGR (0.54) | GCGRNPC1RAB9ASMN1; SMN2GCG | |
| SCHEMBL2654724 | 0.88 | GCGR (0.50) | GCGRGIPR | |
| SCHEMBL2655085 | 0.85 | GCGR (0.46) | GCGRGCGGIPR | |
| SCHEMBL2655675 | 0.85 | GCG (0.47) | GCGRNPC1RAB9ASMN1; SMN2GCG | |
| SCHEMBL2654661 | 0.84 | GCGR (0.55) | GCGRNPC1RAB9ASMN1; SMN2GCG | |
| SCHEMBL2655159 | 0.82 | GCGR (0.46) | GCGRNPC1RAB9ASMN1; SMN2GIPR | |
| SCHEMBL2655470 | 0.81 | GCGR (0.49) | GCGRSMN1; SMN2GCGGIPR | |
| SCHEMBL1765327 | 0.81 | GCGR (0.59) | GCGRGCG | |
| SCHEMBL2654727 | 0.79 | GCGR (0.55) | GCGRGCGGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |