Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.50 |
| ▸ | GIPR | P48546 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.45 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.45 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.45 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.45 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.45 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.45 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.45 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.45 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.45 |
| ▸ | GLP1R | P43220 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656558 | 0.92 | GCGR (0.45) | GCGRGIPRGLP1R | |
| SCHEMBL2654807 | 0.88 | GCGR (0.45) | GCGRGIPR | |
| SCHEMBL2655085 | 0.88 | GCGR (0.46) | GCGRGIPRGLP1R | |
| SCHEMBL2655300 | 0.85 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2654727 | 0.81 | GCGR (0.55) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2653305 | 0.81 | MEN1 (0.48) | GCGRGIPRADCY6ADCY3ADCY9 | |
| SCHEMBL2656186 | 0.81 | GCG (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1765769 | 0.79 | GCGR (0.60) | GCGRGLP1R | |
| SCHEMBL2657400 | 0.79 | GCG (0.50) | GCGRGIPRADCY6ADCY3ADCY9 | |
| SCHEMBL2655470 | 0.79 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |