Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654020 | 0.83 | TYR (0.45) | TYRMAPTCYP3A4MEN1KMT2A | |
| SCHEMBL11081414 | 0.81 | LIPG (0.43) | TYRCYP3A4LIPGELANECTSG | |
| SCHEMBL1237905 | 0.79 | TYR (0.66) | TYRESR2MAPTCYP3A4MEN1 | |
| SCHEMBL2701240 | 0.79 | LIPG (0.50) | TYRCYP3A4ALOX5LIPGELANE | |
| SCHEMBL27884269 | 0.79 | ESR2 (0.53) | ESR2MAPTMEN1KMT2AESR1 | |
| SCHEMBL18770767 | 0.78 | TYR (0.51) | TYRESR2MAPTCYP3A4MEN1 | |
| SCHEMBL330111 | 0.78 | TYR (0.69) | TYRESR2MAPTCYP3A4MEN1 | |
| SCHEMBL31553269 | 0.78 | TYR (0.69) | TYRESR2MAPTCYP3A4MEN1 | |
| SCHEMBL1765205 | 0.77 | TYR (0.49) | TYRESR2MAPTCYP3A4MEN1 | |
| SCHEMBL548498 | 0.76 | ELANE (0.48) | TYRCYP3A4TSHRLIPGELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |