Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ESRRG | P62508 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657107 | 0.90 | S1PR1 (0.66) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2654768 | 0.90 | S1PR1 (0.66) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2656631 | 0.89 | NPC1 (0.67) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2654883 | 0.89 | NPC1 (0.67) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2653059 | 0.88 | NPC1 (0.53) | S1PR1S1PR3S1PR5MEN1KMT2A | |
| SCHEMBL2654665 | 0.88 | FFAR1 (0.59) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2655880 | 0.88 | NPC1 (0.56) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2656088 | 0.88 | S1PR1 (0.55) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2654437 | 0.88 | S1PR1 (0.55) | S1PR1S1PR3S1PR5FFAR1MEN1 | |
| SCHEMBL2653298 | 0.87 | FFAR1 (0.60) | S1PR1S1PR3S1PR5FFAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |