Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662580 | 0.93 | S1PR1 (0.56) | S1PR1S1PR3S1PR5NPC1SMN1; SMN2 | |
| SCHEMBL2654768 | 0.91 | S1PR1 (0.66) | S1PR1S1PR3S1PR5NPC1HDAC3 | |
| SCHEMBL2656088 | 0.89 | S1PR1 (0.55) | S1PR1S1PR3S1PR5NR4A2NPC1 | |
| SCHEMBL2654665 | 0.89 | FFAR1 (0.59) | S1PR1S1PR3S1PR5NPC1HDAC3 | |
| SCHEMBL2655880 | 0.89 | NPC1 (0.56) | S1PR1S1PR3S1PR5NPC1HDAC3 | |
| SCHEMBL2655430 | 0.89 | S1PR1 (0.55) | S1PR1S1PR3S1PR5NR4A2NPC1 | |
| SCHEMBL2655267 | 0.89 | RXRA (0.55) | S1PR1S1PR3S1PR5NPC1HDAC3 | |
| SCHEMBL2653298 | 0.88 | FFAR1 (0.60) | S1PR1S1PR3S1PR5NPC1HDAC3 | |
| SCHEMBL2654896 | 0.88 | S1PR1 (0.60) | S1PR1S1PR3S1PR5NPC1SMN1; SMN2 | |
| SCHEMBL2654015 | 0.88 | MEN1 (0.54) | S1PR1S1PR3S1PR5NPC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |