SCHEMBL26549015

SCHEMBL26549015

CC(C)Nc1cc(C2CCC2)[nH]n1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 1/20 0.52
CDK2 P24941 15/20 0.48
CCNA2 P20248 12/20 0.48
CCNA1 P78396 12/20 0.48
HCAR2 Q8TDS4 1/20 0.46
CDK9 P50750 3/20 0.45
CDK5 Q00535 3/20 0.45
CCNE1 P24864 2/20 0.44
CDK5R1 Q15078 2/20 0.44
CCNT1 O60563 1/20 0.44
PAK3 O75914 1/20 0.44
PAK1 Q13153 1/20 0.44
PAK2 Q13177 1/20 0.44
NTRK1 P04629 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30458326 0.76 CDK2 (0.61) CDK2CCNA2CCNA1HCAR2CDK9
SCHEMBL18176972 0.75 HCAR2 (0.49) IGF1RCDK2CCNA2CCNA1HCAR2
SCHEMBL7175772 0.75 CCNA2 (0.48) IGF1RCDK2CCNA2CCNA1
SCHEMBL2959316 0.74 CCNA2 (0.54) IGF1RCDK2CCNA2CCNA1HCAR2
SCHEMBL17412844 0.72 HCAR2 (0.53) IGF1RCDK2CCNA2CCNA1HCAR2
SCHEMBL15831691 0.71 HCAR2 (0.45) IGF1RCDK2CCNA2CCNA1HCAR2
SCHEMBL27674559 0.71 CCNA2 (0.52) IGF1RCDK2CCNA2CCNA1
SCHEMBL29659491 0.71 CCNA2 (0.70) CDK2CCNA2CCNA1
SCHEMBL15109539 0.71 IGF1R (0.78) IGF1RNTRK1
SCHEMBL6384315 0.70 IGF1R (0.61) IGF1RCDK2CCNA2CCNA1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023196975-A1 COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE SHY THERAPEUTICS, LLC (US) 2023-10-12 WO disclosed