Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.81 |
| ▸ | RARG | P13631 | 2/20 | 0.68 |
| ▸ | RARA | P10276 | 1/20 | 0.66 |
| ▸ | RARB | P10826 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654226 | 0.92 | GCK (0.81) | GCKRARGRARARARB | |
| SCHEMBL14366918 | 0.91 | GCK (0.71) | GCKRARGRARARARB | |
| SCHEMBL2652999 | 0.90 | GCK (1.00) | GCKRARGRARARARB | |
| SCHEMBL5653792 | 0.89 | GCK (1.00) | GCKRARGRARARARB | |
| SCHEMBL2667569 | 0.88 | GCK (0.66) | GCKRARGRARARARB | |
| SCHEMBL14505778 | 0.87 | GCK (0.85) | GCKRARGRARARARB | |
| SCHEMBL2653232 | 0.83 | GCK (0.69) | GCKRARGRARARARB | |
| SCHEMBL2666370 | 0.82 | GCK (0.78) | GCKRARGRARARARB | |
| SCHEMBL2666372 | 0.82 | GCK (0.83) | GCKRARGRARARARB | |
| SCHEMBL14366917 | 0.82 | GCK (0.84) | GCKRARGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070255062-A1 | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | claimed |
| EP-1697324-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | claimed |
| WO-2005054200-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | WO | claimed |
| US-20070255062-A1 | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | disclosed |
| US-20070255062-A1 | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | disclosed |
| US-20070255062-A1 | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | disclosed |
| EP-1697324-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005054200-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070255062-A1 | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | GCK, GALK1, PDXK | GCK 1/4885RARG 3734/4885RARA 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.