Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GCG | P01275 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655245 | 0.93 | GCG (0.42) | RAB9ANPC1SMN1; SMN2GCGGCGR | |
| SCHEMBL2655097 | 0.89 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1HDAC6 | |
| SCHEMBL2654250 | 0.86 | NPC1 (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1HDAC6 | |
| SCHEMBL2655241 | 0.82 | GCG (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1765582 | 0.82 | GCGR (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1SCN5A | |
| SCHEMBL2654785 | 0.81 | NPC1 (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1HDAC6 | |
| SCHEMBL2654806 | 0.81 | GCGR (0.49) | RAB9ANPC1SMN1; SMN2GCGGCGR | |
| SCHEMBL2655131 | 0.81 | GCG (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1GCG | |
| SCHEMBL2654789 | 0.80 | GCG (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1GCG | |
| SCHEMBL2656241 | 0.80 | PPARD (0.42) | GCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |