Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273866 | 1.00 | NPC1 (0.54) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL266482 | 0.91 | NPC1 (0.58) | NPC1RAB9APKMPOLBMEN1 | |
| SCHEMBL273711 | 0.91 | NPC1 (0.58) | NPC1RAB9APKMPOLBMEN1 | |
| SCHEMBL273718 | 0.90 | NPC1 (0.57) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL268003 | 0.90 | NPC1 (0.57) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL273703 | 0.89 | MAPT (0.59) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL266718 | 0.89 | MAPT (0.59) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL273860 | 0.88 | MAPT (0.69) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL268023 | 0.88 | MAPT (0.69) | NPC1RAB9APKMPOLBMAPT | |
| SCHEMBL273516 | 0.87 | NPC1 (0.53) | NPC1RAB9APKMPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134015-B2 | Compound inhibiting in vivo phosphorous transport and medicine containing the same | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-03-13 | — | — | US | disclosed |