Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.69 |
| ▸ | HLCS | P50747 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | IDE | P14735 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 3/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.63 |
| ▸ | CA2 | P00918 | 3/20 | 0.63 |
| ▸ | CA9 | Q16790 | 3/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036929 | 1.00 | TDP1 (0.69) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL24179756 | 1.00 | TDP1 (0.69) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL12735634 | 1.00 | TDP1 (0.69) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL22560803 | 1.00 | TDP1 (0.69) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL10063351 | 1.00 | TDP1 (0.69) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL17881931 | 0.97 | TDP1 (0.71) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL16923825 | 0.97 | TDP1 (0.71) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL13166618 | 0.96 | TDP1 (0.64) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL17128734 | 0.94 | TDP1 (0.67) | TDP1HLCSPKMMEN1ABL1 | |
| SCHEMBL12085208 | 0.94 | TDP1 (0.70) | TDP1HLCSPKMMEN1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |