Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RORA | P35398 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200877 | 0.76 | KMT2A (0.53) | MEN1KMT2ARORARORCRORB | |
| SCHEMBL1925589 | 0.74 | GAA (0.47) | MEN1KMT2ATSHRALDH1A1GAA | |
| SCHEMBL7654081 | 0.72 | SLC1A3 (0.45) | MEN1KMT2ARORARORCRORB | |
| SCHEMBL27848729 | 0.71 | KAT6A (0.47) | TSHRALDH1A1 | |
| SCHEMBL1926109 | 0.71 | MCL1 (0.43) | MEN1KMT2ACYP2C19SLC1A3SLC1A2 | |
| SCHEMBL27865607 | 0.70 | CA1 (0.50) | MEN1KMT2AALDH1A1SLC1A3SLC1A2 | |
| SCHEMBL28163455 | 0.70 | KDM4E (0.35) | TSHRNPC1MAPT | |
| SCHEMBL27795033 | 0.70 | MMP1 (0.49) | MEN1KMT2ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8232303 | 0.69 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28978077 | 0.69 | CYP2D6 (0.62) | MEN1KMT2ARORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101573357-B | Indole compound | TAKAEDA CHEMICAL IND LTD | 2013-01-23 | — | — | CN | disclosed |
| CN-101573357-A | Indole compound | TAKEDA PHARMACEUTICAL (JP) | 2009-11-04 | — | — | CN | disclosed |
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |