Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 16/20 | 0.51 |
| ▸ | GIPR | P48546 | 5/20 | 0.45 |
| ▸ | GCG | P01275 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657436 | 0.90 | GCGR (0.54) | GCGRGIPRPPARDPPARA | |
| SCHEMBL2655298 | 0.89 | FFAR1 (0.49) | GCGRGIPRGCGEPHX2FFAR1 | |
| SCHEMBL2654697 | 0.85 | GCGR (0.55) | GCGRGIPRGCGPPARDPPARA | |
| SCHEMBL2654856 | 0.85 | GCGR (0.49) | GCGRGIPRGCGPPARD | |
| SCHEMBL2656116 | 0.84 | GCGR (0.55) | GCGRGIPRGCGPPARDPPARA | |
| SCHEMBL2657426 | 0.81 | GCGR (0.46) | GCGRGIPREPHX2PPARDPPARA | |
| SCHEMBL2653879 | 0.81 | GCGR (0.57) | GCGREPHX2 | |
| SCHEMBL2657509 | 0.80 | ROCK2 (0.41) | GCGREPHX2FFAR1PPARDPPARA | |
| SCHEMBL2653639 | 0.79 | GCGR (0.56) | GCGRGIPRGCGPPARDPPARA | |
| SCHEMBL2656273 | 0.79 | GCGR (0.54) | GCGRGIPRGCGEPHX2PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951661-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007106181-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-09-20 | — | — | WO | claimed |
| EP-1951661-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007106181-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-09-20 | — | — | WO | disclosed |