Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662076 | 0.83 | GCK (0.47) | GCK | |
| SCHEMBL2667836 | 0.79 | GCK (0.55) | GCKKMT2A | |
| SCHEMBL2661799 | 0.79 | GCK (0.50) | GCK | |
| SCHEMBL1043196 | 0.78 | GCK (0.49) | GCK | |
| SCHEMBL19793113 | 0.73 | GCK (0.54) | GCK | |
| SCHEMBL19793123 | 0.73 | GCK (0.54) | GCK | |
| SCHEMBL2662402 | 0.71 | GCK (0.43) | GCK | |
| SCHEMBL2656402 | 0.70 | MEN1 (0.64) | GCKMEN1KMT2A | |
| SCHEMBL1262231 | 0.70 | MEN1 (0.46) | GCKMEN1KMT2A | |
| SCHEMBL2667868 | 0.69 | CA1 (0.45) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078000-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008050117-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |