Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659188 | 0.90 | GCK (0.42) | GCK | |
| SCHEMBL2656050 | 0.83 | GCK (0.57) | GCK | |
| SCHEMBL2662332 | 0.82 | GCK (0.44) | GCK | |
| SCHEMBL1043884 | 0.78 | GCK (0.54) | GCK | |
| SCHEMBL2655275 | 0.78 | GCK (0.43) | GCK | |
| SCHEMBL2087584 | 0.75 | GCK (0.66) | GCK | |
| SCHEMBL2655362 | 0.71 | GCK (0.39) | GCK | |
| SCHEMBL2075157 | 0.70 | GCK (0.49) | GCKF10SCN9A | |
| SCHEMBL1041008 | 0.70 | CA12 (0.44) | GCKF2 | |
| SCHEMBL1040935 | 0.69 | GCK (0.55) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078000-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008050117-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |