Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265563 | 1.00 | TACR1 (0.40) | TACR1SLC6A9P2RX7PSEN1PSEN2 | |
| SCHEMBL265565 | 1.00 | TACR1 (0.40) | TACR1SLC6A9P2RX7PSEN1PSEN2 | |
| SCHEMBL264115 | 0.88 | TACR1 (0.39) | TACR1TRPM8KMT2A | |
| SCHEMBL264116 | 0.88 | TACR1 (0.39) | TACR1TRPM8KMT2A | |
| SCHEMBL264114 | 0.88 | TACR1 (0.39) | TACR1TRPM8KMT2A | |
| SCHEMBL8086085 | 0.85 | TACR1 (0.42) | TACR1SLC6A9MLYCDPLAAT3PLAAT5 | |
| SCHEMBL3649918 | 0.84 | TACR1 (0.44) | TACR1SLC6A9MLYCDMEN1KMT2A | |
| SCHEMBL3643397 | 0.84 | TACR1 (0.44) | TACR1TRPM8MEN1KMT2AMDM2 | |
| SCHEMBL3645996 | 0.84 | TACR1 (0.44) | TACR1SLC6A9MLYCDMEN1KMT2A | |
| SCHEMBL3645993 | 0.84 | TACR1 (0.44) | TACR1SLC6A9MLYCDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133909-B2 | Heteroaromatic monoamides as orexinin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | TACR1 60/4885SLC6A9 4467/4885P2RX7 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.