Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655103 | 0.95 | GCGR (0.47) | GCGRPPARAMEN1KMT2AMAPT | |
| SCHEMBL2654727 | 0.92 | GCGR (0.55) | GCGRPPARAMEN1KMT2APPARD | |
| SCHEMBL2653412 | 0.91 | PSEN1 (0.44) | GCGRPPARAMAPTPPARDNPC1 | |
| SCHEMBL2661394 | 0.90 | MEN1 (0.48) | PPARAMEN1KMT2AMAPTROCK2 | |
| SCHEMBL2655159 | 0.89 | GCGR (0.46) | GCGRMAPTESRRGNPC1RAB9A | |
| SCHEMBL2654812 | 0.88 | GCGR (0.51) | GCGRMEN1KMT2AMAPTESRRG | |
| SCHEMBL2653584 | 0.87 | GCGR (0.56) | GCGRPPARAPPARD | |
| SCHEMBL2652666 | 0.87 | TRPV1 (0.46) | GCGRTRPV1 | |
| SCHEMBL2653229 | 0.84 | GCGR (0.47) | GCGRPPARAMEN1KMT2AMAPT | |
| SCHEMBL2655470 | 0.83 | GCGR (0.49) | GCGRPPARAPPARDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |