Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 8/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26559944 | 0.88 | HTT (0.50) | HTTPRKDCPDE3ADYRK1AENPP1 | |
| SCHEMBL26563955 | 0.86 | ENPP1 (0.49) | PRKDCPDE3AENPP1PDGFRBPDE10A | |
| SCHEMBL26564041 | 0.86 | PRKDC (0.39) | PRKDCPDE3ADYRK1AENPP1JAK3 | |
| SCHEMBL26563764 | 0.85 | PRKDC (0.47) | HTTCHRM4PRKDCTP53 | |
| SCHEMBL26559608 | 0.84 | ENPP1 (0.39) | PRKDCPDE3AENPP1JAK3 | |
| SCHEMBL26563914 | 0.84 | HTT (0.55) | HTTCHRM4PRKDCTP53PDE3A | |
| SCHEMBL30562899 | 0.82 | HTT (0.50) | HTTCHRM4PRKDCDYRK1AENPP1 | |
| SCHEMBL21664258 | 0.82 | HTT (0.50) | HTTCHRM4PRKDCDYRK1AENPP1 | |
| SCHEMBL26564201 | 0.82 | JAK2 (0.41) | PRKDCPDE3AENPP1PDE10AJAK3 | |
| SCHEMBL26552621 | 0.82 | HTT (0.49) | HTTCHRM4PRKDCTP53PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |