Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 5/20 | 0.39 |
| ▸ | GIPR | P48546 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654683 | 0.93 | GCGR (0.46) | GCGRMCL1GIPR | |
| SCHEMBL2653834 | 0.92 | PPARD (0.36) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2656753 | 0.87 | PPARD (0.42) | PPARDPPARAPPARG | |
| SCHEMBL2666526 | 0.86 | MCL1 (0.46) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2653235 | 0.86 | MCL1 (0.43) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2654440 | 0.85 | GCGR (0.47) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2662579 | 0.85 | MCL1 (0.42) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2654856 | 0.85 | GCGR (0.49) | GCGRPPARDGIPR | |
| SCHEMBL2655204 | 0.85 | GCGR (0.42) | GCGRMCL1PPARDGIPRPPARA | |
| SCHEMBL2661440 | 0.84 | PPARD (0.37) | GCGRMCL1PPARDGIPRPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |