Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.48 |
| ▸ | GCGR | P47871 | 11/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GIPR | P48546 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654997 | 0.92 | GCGR (0.53) | TRPV1GCGRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2653745 | 0.90 | GCGR (0.49) | TRPV1GCGREPHX2NR1H4 | |
| SCHEMBL2653388 | 0.89 | GCGR (0.49) | GCGREPHX2NR1H4 | |
| SCHEMBL2652666 | 0.86 | TRPV1 (0.46) | TRPV1GCGRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2654850 | 0.83 | GCGR (0.53) | GCGRGIPREPHX2 | |
| SCHEMBL2655916 | 0.83 | PPARD (0.49) | TRPV1GCGR | |
| SCHEMBL2654466 | 0.82 | MEN1 (0.56) | — | |
| SCHEMBL2653990 | 0.82 | MEN1 (0.56) | — | |
| SCHEMBL2655457 | 0.81 | NPC1 (0.44) | — | |
| SCHEMBL2653848 | 0.81 | RARB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |