Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654648 | 0.92 | RARB (0.45) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2654924 | 0.92 | RARB (0.52) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2655916 | 0.90 | PPARD (0.49) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2652991 | 0.89 | NPC1 (0.53) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2653408 | 0.84 | RARB (0.49) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2654911 | 0.84 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2APPARD | |
| SCHEMBL2653706 | 0.84 | RARB (0.48) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2655125 | 0.83 | GCGR (0.49) | RARBNPC1RAB9AMAPTS1PR1 | |
| SCHEMBL2656949 | 0.82 | NPC1 (0.48) | RARBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2653422 | 0.82 | PPARD (0.51) | RARBMEN1KMT2AS1PR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |