Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654863 | 0.89 | ESRRG (0.45) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2657400 | 0.83 | GCG (0.50) | NPC1RAB9ANR1H4EPHX2ESRRG | |
| SCHEMBL2654602 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2654032 | 0.78 | ESRRG (0.47) | SMN1; SMN2MAPTNPC1RAB9ANR1H4 | |
| SCHEMBL1765723 | 0.77 | GCG (0.46) | SMN1; SMN2MAPTLMNAALDH1A1ALOX15 | |
| SCHEMBL2656186 | 0.76 | GCG (0.49) | MEN1KMT2A | |
| SCHEMBL2654566 | 0.73 | KMT2A (0.54) | SMN1; SMN2MAPTLMNAALDH1A1NPC1 | |
| SCHEMBL2654622 | 0.71 | GCG (0.53) | NPC1RAB9ANR1H4MEN1EPHX2 | |
| SCHEMBL2661394 | 0.71 | MEN1 (0.48) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL2654487 | 0.70 | MEN1 (0.48) | SMN1; SMN2MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |