Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | FABP2 | P12104 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | GLP1R | P43220 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653572 | 0.85 | MEN1 (0.59) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2654251 | 0.85 | MEN1 (0.59) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2654863 | 0.85 | ESRRG (0.45) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2661394 | 0.81 | MEN1 (0.48) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2655814 | 0.81 | MEN1 (0.42) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2653412 | 0.80 | PSEN1 (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1PPARA | |
| SCHEMBL2653473 | 0.79 | ESRRG (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1PPARA | |
| SCHEMBL2657400 | 0.77 | GCG (0.50) | NPC1RAB9AGLP1RGCGRESRRG | |
| SCHEMBL2655159 | 0.77 | GCGR (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1GCGR | |
| SCHEMBL2656186 | 0.76 | GCG (0.49) | KMT2AMEN1PPARAGLP1RGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |