Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26563914 | 0.94 | HTT (0.55) | HTTCHRM4ALDH1A1NPSR1ENPP1 | |
| SCHEMBL26561866 | 0.93 | HTT (0.62) | HTTCHRM4LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL26563939 | 0.85 | PRKDC (0.48) | HTTENPP1PDE3ACYP1A2CYP2D6 | |
| SCHEMBL26564345 | 0.83 | HTT (0.53) | HTTCHRM4LMNAALDH1A1NPSR1 | |
| SCHEMBL26552621 | 0.83 | HTT (0.49) | HTTCHRM4ENPP1PDGFRBPDE3A | |
| SCHEMBL21664250 | 0.83 | HTT (0.52) | HTTCHRM4HTR1AHTR7LMNA | |
| SCHEMBL30562933 | 0.83 | HTT (0.52) | HTTCHRM4HTR1AHTR7LMNA | |
| SCHEMBL21456825 | 0.82 | HTT (0.57) | HTTCHRM4HTR1AHTR7ENPP1 | |
| SCHEMBL26559097 | 0.81 | PRKDC (0.41) | HTTENPP1PDGFRBPDE3A | |
| SCHEMBL26559069 | 0.81 | HRH4 (0.44) | HTR1AHTR7PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |