Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 5/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26563914 | 0.88 | HTT (0.55) | PRKDCJAK3PDE3ANAMPTDYRK1A | |
| SCHEMBL26564041 | 0.86 | PRKDC (0.39) | PRKDCJAK3PDE3ANAMPTPRKAB2 | |
| SCHEMBL26551781 | 0.86 | ENPP1 (0.51) | PRKDCPDE3ACYP3A4ENPP1PDGFRB | |
| SCHEMBL26559090 | 0.85 | LRRK2 (0.46) | PRKDCPDE3ACYP3A4 | |
| SCHEMBL26559069 | 0.85 | HRH4 (0.44) | PRKDCNAMPT | |
| SCHEMBL26564090 | 0.84 | DYRK1A (0.45) | PRKDCPDE3ADYRK1ACYP3A4ENPP1 | |
| SCHEMBL26553056 | 0.83 | PRKDC (0.60) | PRKDC | |
| SCHEMBL26559027 | 0.83 | ENPP1 (0.43) | PRKDCJAK3PDE3APRKAB2PRKAG1 | |
| SCHEMBL26559036 | 0.81 | ENPP1 (0.60) | PDE3AENPP1 | |
| SCHEMBL26564377 | 0.81 | HTT (0.57) | PDE3AENPP1PDGFRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |